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AGIOS PHARMACEUTICALS, INC.

AGIO

$34.98 ▲ +1.04 (+3.06%) at close

16 Visible periods

28 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

AGIOS PHARMACEUTICALS, INC. faces fundamental challenges with weakness in Return on Common Equity (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $2.0B

Dividend Yield —

Revenue Growth 48.0% ↗

Op. Margin None

ROIC -39.5% ↘

FCF / Share $-6.51 ↗

Trailing P/E —

Price / Book 1.7x

FCF Yield —

Debt / Equity —

info Valuation on last close. End-of-day price, Sep 22, 2026.

16-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$54.03M

↑ +48.0% —

Net Income Profit after all expenses

$-412.78M

↓ -161.3% —

Operating Margin Operating profit as % of sales

-361.6%

↑ +5.9% —

FCF / Share Free cash flow per share

$-6.51

↑ +5.6% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Return on Common Equity (%)Return on Common Equity (%) is in the bottom quartile

Health Breakdown

Returns

Cash Quality

Financial view

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📈 Is growth accelerating? 7 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Revenue Growth YoY (%)	48.0% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+500%)	36.1% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+351%)	88.4% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1005%)	—	—	—	24.9% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+212%)	119.4% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1393%)	-38.5% Weak Weak Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-581%)	—	—	155.8% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1848%)	1.8% Caution Caution Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-78%)	15.0% Good Good Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+87%)	—	—
EPS Growth YoY (%)	N/M	N/M	-49.6% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	N/M	N/M	—	—	—	—	—	—	—	—	—	—	—
Net Income Growth YoY (%)	N/M	N/M	-51.9% Weak Weak Year-over-year change in net income	N/M	N/M	20.4% Good ↑ Good Improving Year-over-year change in net income	-18.9% Weak ↑ Weak Improving Year-over-year change in net income	-10.0% Weak ↑ Weak Improving Year-over-year change in net income	-58.5% Weak ↑ Weak Improving Year-over-year change in net income	-68.6% Weak ↑ Weak Improving Year-over-year change in net income	-120.0% Weak ↓ Weak Declining Year-over-year change in net income	-35.8% Weak ↑ Weak Improving Year-over-year change in net income	-96.0% Weak Weak Year-over-year change in net income	15.2% Good Good Year-over-year change in net income	—	—
FCF Growth YoY (%)	5.6% Fair ↑ Fair Improving Year-over-year change in free cash flow	-29.1% Weak ↓ Weak Declining Year-over-year change in free cash flow	7.0% Fair ↑ Fair Improving Year-over-year change in free cash flow	16.0% Good Good Year-over-year change in free cash flow	-54.7% Weak Weak Year-over-year change in free cash flow	—	—	—	—	—	—	—	—	—	—	—
Revenue CAGR 3Y (%)	56.0% Excellent Excellent Compound annual revenue growth over 3 years	—	—	-50.6% Weak Weak Compound annual revenue growth over 3 years	—	—	19.0% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	—	-13.0% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	39.9% Excellent Excellent Compound annual revenue growth over 3 years	—	44.1% Excellent Excellent Compound annual revenue growth over 3 years	—	—	—	—
Revenue CAGR 5Y (%)	—	-20.9% Weak → Weak Stable Compound annual revenue growth over 5 years	-22.2% Weak Weak Compound annual revenue growth over 5 years	-19.8% Weak Weak Compound annual revenue growth over 5 years	—	—	12.5% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	29.9% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	11.4% Good Good Compound annual revenue growth over 5 years	26.2% Excellent Excellent Compound annual revenue growth over 5 years	—	—	—	—	—	—
EPS CAGR 3Y (%)	—	-23.6% Weak Weak Compound annual EPS growth over 3 years	—	—	—	—	—	—	—	—	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Operating Margin (%) (%)	—	—	—	—	—	—	-361.6% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2510%)	-384.0% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2660%)	—	-287.6% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2017%)	—	-82.8% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-652%)	-152.2% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1115%)	-91.6% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-711%)	-76.2% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-608%)	—
Effective Tax Rate (%) (%)	0.2% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	6.2% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—	—	—	—	—	0.8% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-1.5% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	12.3% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-43.7% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—
Profit Margin (%) (%)	—	—	—	—	—	—	-349.0% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-3008%)	-366.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-3155%)	—	-284.0% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2466%)	—	-81.9% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-782%)	-154.2% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1385%)	-80.1% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-767%)	-108.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1005%)	—
FCF Margin (%) (%)	—	—	—	—	—	—	-324.6% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-329.9% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	41.0% Excellent Excellent Free cash flow as a percentage of revenue Optimal: > 10%	—	—	-225.8% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-203.2% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-78.4% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—
FCF / Net Income (x)	0.91x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	-0.58x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.84x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	1.36x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	-0.26x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.93x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.93x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.90x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.92x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	-0.14x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	—	—	1.46x Good ↓ Good Declining Free cash flow relative to reported net income Optimal: > 1x	2.54x Excellent Excellent Free cash flow relative to reported net income Optimal: > 1x	0.72x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Return on Invested Capital (%)	-39.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-25.9% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-48.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-27.9% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-23.1% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-66.4% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-52.6% Weak → Weak Stable Return earned on debt + equity capital invested Optimal: > 10%	-41.6% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-67.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-44.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-27.2% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-12.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-30.0% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	28.0% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	45.3% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	—
Return on Capital (%) (%)	-36.4% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-25.6% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-41.8% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-31.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-26.3% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-39.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-47.9% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-42.2% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-52.2% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-32.5% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-28.3% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-11.0% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-19.3% Weak Weak Operating profit relative to total assets Optimal: > 10%	-16.8% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	-34.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-331%)	43.7% Excellent ↑ Excellent Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+191%)	-43.4% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-389%)	-21.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-240%)	124.2% Excellent ↑ Excellent Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+728%)	-81.9% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-646%)	-64.2% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-528%)	-50.3% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-436%)	-83.8% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-659%)	-55.3% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-469%)	-34.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-327%)	-12.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-184%)	-30.0% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-300%)	27.9% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+86%)	44.9% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+199%)	—

⚖️ Is the balance sheet risky? 1 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Net Debt (USD)	$-89.13M	$-76.25M	$-88.20M	$-139.26M	$-203.13M	$-127.44M	$-80.93M	$-70.50M	$-102.72M	$-160.75M	$-71.76M	$-14.03M	$-71.56M	$-91.30M	$-117.66M	$-77.88M

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Revenue per Share (USD)	$0.93	$0.64	$0.48	$0.26	$0.00	—	—	—	—	—	—	—	—	—	—	—
Basic EPS, GAAP (USD)	$-7.12	$11.86	$-6.33	$-4.23	$26.55	$-4.74	—	—	—	—	—	—	—	—	—	—
Free Cash Flow per Share (USD)	$-6.51	$-6.89	$-5.34	$-5.74	$-6.83	$-4.42	—	—	—	—	—	—	—	—	—	—
Book Value per Share (USD)	$20.41	$26.96	$14.50	$20.00	$23.78	$5.77	$9.36	$11.81	$7.69	$8.49	$9.16	$11.44	$4.21	$-19.92	—	—
Tangible Book Value per Share (USD)	$20.41	$26.96	$14.50	$20.00	$23.78	$5.77	$9.36	$11.81	$7.69	$8.49	$9.16	$11.44	$4.21	$-19.92	—	—
Basic Weighted Avg Shares (shares)	57.97M	56.81M	55.65M	54.79M	60.45M	69.00M	—	—	—	—	—	—	—	—	—	—

🏦 How resilient is the balance sheet? 2 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Working Capital (USD)	$859.85M	$884.44M	$765.88M	$770.14M	$1.00B	$542.28M	$518.82M	$520.28M	$350.32M	$471.46M	$284.44M	$298.46M	$132.82M	$95.03M	—	—
Total Equity (USD)	$1.19B	$1.54B	$811.02M	$1.10B	$1.29B	$399.50M	$640.53M	$687.54M	$375.50M	$358.59M	$345.12M	$424.37M	$131.48M	$-72.02M	$-52.78M	$-29.59M

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗
Sales/Revenue/Turnover (USD)	$54.03M	$36.50M	$26.82M	$14.24M	$0.00	—	$117.91M	$94.39M	$43.01M	$69.89M	—	$65.36M	$25.55M	$25.11M	$21.84M	—
Depreciation Expense (USD)	$5.20M	$5.70M	$6.60M	$8.40M	$8.80M	$9.40M	$8.09M	$7.17M	$6.43M	$5.71M	$3.34M	$1.37M	$1.44M	$1.18M	$801.00K	—
Net Income, GAAP (USD)	$-412.78M	$673.73M	$-352.09M	$-231.80M	$1.60B	$-327.37M	$-411.47M	$-346.03M	$-314.67M	$-198.47M	$-117.73M	$-53.50M	$-39.41M	$-20.10M	$-23.71M	—
Operating Cash Flow (USD)	$-372.98M	$-389.84M	$-296.06M	$-309.48M	$-407.32M	$-290.76M	$-370.62M	$-304.42M	$-285.23M	$38.56M	—	—	$-56.40M	$-49.55M	$-15.22M	—

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bar_chart Data from SEC EDGAR XBRL filings

Synced yesterday 16 years · 59 quarters

AGIOS PHARMACEUTICALS, INC.

Analytical Summary

16-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

Statement lens

Benchmark Lens

Signals

Percentile Rankings

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