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ANAPTYSBIO, INC

ANAB

$50.81 ▼ -3.16 (-5.85%) at close

12 Visible periods

28 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Weak

Moderately Bearish

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Analytical Summary

ANAPTYSBIO, INC faces fundamental challenges with weakness in Return on Common Equity (%) and Profit Margin (%). On the positive side, Operating Margin (%) remains strong. Investors should exercise caution and monitor for improvement in key metrics.

Market Cap $1.5B

Dividend Yield —

Revenue Growth 157.0% ↘

Op. Margin 20.4% ↗

ROIC 130.3% ↗

FCF / Share $0.68 ↗

Trailing P/E —

Price / Book 38.3x

FCF Yield 1.3%

Debt / Equity —

info Valuation on last close. End-of-day price, Sep 23, 2026.

12-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$234.60M

↑ +157.0% —

Net Income Profit after all expenses

$-13.23M

↑ +90.9% —

Operating Margin Operating profit as % of sales

20.4%

↑ +116.2% 76th

FCF / Share Free cash flow per share

$0.68

↑ +114.3% —

trending_up

Bullish Indicators

Operating Margin (%)Operating Margin (%) is in the top quartile

warning

Bearish Risks

Profit Margin (%)Profit Margin (%) is in the bottom quartile
Return on Common Equity (%)Return on Common Equity (%) is in the bottom quartile

Health Breakdown

Profitability ↑

Returns ↓

Financial Health

Cash Quality

Financial view

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📈 Is growth accelerating? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Revenue Growth YoY (%)	157.0% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1863%)	432.0% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+5300%)	66.8% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+735%)	-83.7% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-1146%)	-15.8% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-297%)	837.5% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+10369%)	60.0% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+650%)	-50.0% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-725%)	-40.1% Weak Weak Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-601%)	-5.0% Weak Weak Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-163%)	—	—
EPS Growth YoY (%)	91.0% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	15.8% Good ↑ Good Improving Year-over-year change in earnings per share Optimal: > 10%	-33.0% Weak ↑ Weak Improving Year-over-year change in earnings per share Optimal: > 10%	-116.6% Weak ↓ Weak Declining Year-over-year change in earnings per share Optimal: > 10%	-189.0% Weak ↓ Weak Declining Year-over-year change in earnings per share Optimal: > 10%	79.7% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	-44.0% Weak ↓ Weak Declining Year-over-year change in earnings per share Optimal: > 10%	-64.5% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	6.2% Fair Fair Year-over-year change in earnings per share Optimal: > 10%	—	—	—
Net Income Growth YoY (%)	90.9% Excellent ↑ Excellent Improving Year-over-year change in net income	11.2% Fair ↑ Fair Improving Year-over-year change in net income	-27.1% Weak ↑ Weak Improving Year-over-year change in net income	-122.7% Weak ↓ Weak Declining Year-over-year change in net income	-190.0% Weak ↓ Weak Declining Year-over-year change in net income	79.5% Excellent ↑ Excellent Improving Year-over-year change in net income	-57.9% Weak ↑ Weak Improving Year-over-year change in net income	-105.0% Weak ↑ Weak Improving Year-over-year change in net income	-606.0% Weak Weak Year-over-year change in net income	21.2% Good Good Year-over-year change in net income	—	—
FCF Growth YoY (%)	N/M	-5.9% Weak ↑ Weak Improving Year-over-year change in free cash flow	-72.0% Weak ↑ Weak Improving Year-over-year change in free cash flow	-52.3% Weak Weak Year-over-year change in free cash flow	-219.6% Weak Weak Year-over-year change in free cash flow	—	—	—	—	—	—	—
Revenue CAGR 3Y (%)	183.6% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	13.1% Good ↓ Good Declining Compound annual revenue growth over 3 years	-38.8% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	8.7% Fair ↓ Fair Declining Compound annual revenue growth over 3 years	132.9% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	95.7% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	-21.7% Weak Weak Compound annual revenue growth over 3 years	-34.2% Weak Weak Compound annual revenue growth over 3 years	—	—	—	—
Revenue CAGR 5Y (%)	25.6% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	62.7% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	28.0% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	0.6% Weak ↓ Weak Declining Compound annual revenue growth over 5 years	30.5% Excellent Excellent Compound annual revenue growth over 5 years	33.7% Excellent Excellent Compound annual revenue growth over 5 years	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Operating Margin (%) (%)	20.4% Good Good Operating income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+36%)	-125.9% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-940%)	—	—	-89.9% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-700%)	-31.8% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-312%)	—	—	-287.8% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2019%)	-18.1% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-221%)	-18.9% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-226%)	—
Effective Tax Rate (%) (%)	-1.3% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.0% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.2% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.3% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-2.6% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—
Profit Margin (%) (%)	-5.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-147%)	-159.1% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1426%)	—	—	-91.5% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-862%)	-26.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-321%)	—	—	-300.7% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2606%)	-25.5% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-313%)	-30.8% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-356%)	—
FCF Margin (%) (%)	8.4% Caution Caution Free cash flow as a percentage of revenue Optimal: > 10%	-148.7% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	-74.8% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-19.6% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	-197.3% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-54.4% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-56.5% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—
FCF / Net Income (x)	-1.48x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.93x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.74x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.57x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.82x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.74x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.72x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	0.80x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	0.66x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	2.13x Excellent Excellent Free cash flow relative to reported net income Optimal: > 1x	1.84x Excellent Excellent Free cash flow relative to reported net income Optimal: > 1x	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Return on Invested Capital (%)	130.3% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	-162.2% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-186.6% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-43.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-15.9% Weak → Weak Stable Return earned on debt + equity capital invested Optimal: > 10%	-6.0% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-26.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-13.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-9.4% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	7.9% Fair Fair Return earned on debt + equity capital invested Optimal: > 10%	9.7% Fair Fair Return earned on debt + equity capital invested Optimal: > 10%	—
Return on Capital (%) (%)	13.1% Good ↑ Good Improving Operating profit relative to total assets Optimal: > 10%	-23.8% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-36.3% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-18.9% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-8.8% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-5.7% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-24.7% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-13.1% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-8.7% Weak Weak Operating profit relative to total assets Optimal: > 10%	-4.9% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	-35.6% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-337%)	-204.9% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1466%)	-185.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1338%)	-49.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-427%)	-16.2% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-208%)	-5.0% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-133%)	-24.0% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-260%)	-12.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-185%)	-9.8% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-165%)	11.1% Fair Fair Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-26%)	15.4% Good Good Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: At sector avg	—

⚖️ Is the balance sheet risky? 2 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Interest Coverage (x)	0.60x Weak Weak Operating income divided by interest expense Optimal: > 5x	-2.73x Weak Weak Operating income divided by interest expense Optimal: > 5x	—	—	—	—	-103.20x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-40.39x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-16.21x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-6.60x Weak Weak Operating income divided by interest expense Optimal: > 5x	-7.22x Weak Weak Operating income divided by interest expense Optimal: > 5x	—
Net Debt (USD)	$-238.20M	$-123.08M	$-35.97M	$-71.31M	$-495.73M	$-250.46M	$-171.02M	$-113.60M	$-81.19M	$-51.23M	—	—

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Revenue per Share (USD)	$8.16	$3.22	$0.64	$0.37	$2.30	$2.75	—	—	—	—	—	—
Basic EPS, GAAP (USD)	$-0.46	$-5.12	$-6.08	$-4.57	$-2.11	$-0.73	$-3.60	$-2.50	$-1.52	$-1.62	—	—
Free Cash Flow per Share (USD)	$0.68	$-4.78	$-4.52	$-2.63	$-1.72	$-0.54	—	—	—	—	—	—
Book Value per Share (USD)	$1.33	$2.33	$3.31	$9.19	$12.89	$14.50	$14.86	$18.07	$12.93	$-14.43	—	—
Tangible Book Value per Share (USD)	$1.33	$2.33	$3.31	$9.19	$12.89	$14.50	$14.86	$18.07	$12.93	$-14.43	—	—
Basic Weighted Avg Shares (shares)	28.76M	28.38M	26.92M	28.16M	27.43M	27.30M	—	—	—	—	—	—

🏦 How resilient is the balance sheet? 2 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Working Capital (USD)	$311.62M	$386.45M	$369.39M	$421.15M	$537.78M	$376.74M	$348.20M	$412.38M	$238.61M	$52.50M	—	—
Total Equity (USD)	$37.21M	$70.87M	$88.10M	$262.10M	$356.43M	$396.73M	$405.01M	$486.37M	$307.58M	$-38.25M	$-35.18M	$-30.84M

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Sales/Revenue/Turnover (USD)	$234.60M	$91.28M	$17.16M	$10.29M	$63.17M	$75.00M	$8.00M	$5.00M	$10.00M	$16.68M	$17.57M	—
Depreciation Expense (USD)	$559.00K	$606.00K	$652.00K	$675.00K	$619.00K	$559.00K	$514.00K	$315.00K	$183.00K	$233.00K	$274.00K	—
Net Income, GAAP (USD)	$-13.23M	$-145.23M	$-163.62M	$-128.72M	$-57.80M	$-19.93M	$-97.34M	$-61.66M	$-30.07M	$-4.26M	$-5.41M	—
Operating Cash Flow (USD)	$19.70M	$-135.34M	$-120.80M	$-73.59M	$-45.92M	$-14.16M	$-69.52M	$-48.51M	$-19.44M	$-9.03M	$-9.69M	—

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Synced yesterday 12 years · 43 quarters

ANAPTYSBIO, INC

Analytical Summary

12-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

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