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Axsome Therapeutics, Inc.

AXSM

$129.90 ▼ -7.05 (-5.15%) at close

13 Visible periods

30 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

Axsome Therapeutics, Inc. faces fundamental challenges with weakness in Return on Common Equity (%) and Profit Margin (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $6.5B

Dividend Yield —

Revenue Growth 65.5% ↗

Op. Margin -26.1% ↗

ROIC -80.7% ↗

FCF / Share $-1.89 ↗

Trailing P/E —

Price / Book 74.9x

FCF Yield —

Debt / Equity 1.33

info Valuation on last close. End-of-day price, Nov 5, 2026.

13-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$638.50M

↑ +65.5% —

Net Income Profit after all expenses

$-183.17M

↑ +36.2% —

Operating Margin Operating profit as % of sales

-26.1%

↑ +64.1% 9th

FCF / Share Free cash flow per share

$-1.89

↑ +29.7% —

Long-Term Debt Long-term obligations

$117.75M

↓ -34.8% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Debt to EquityDebt to Equity is concerning (bottom quartile)
Operating Margin (%)Operating Margin (%) is in the bottom quartile
Profit Margin (%)Profit Margin (%) is in the bottom quartile
Return on Common Equity (%)Return on Common Equity (%) is in the bottom quartile

Health Breakdown

Profitability ↑

Returns ↓

Financial Health →

Cash Quality ↓

Financial view

Statement lens

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📈 Is growth accelerating? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Revenue Growth YoY (%)	65.5% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+719%)	42.5% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+432%)	440.8% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+5410%)	—	—	—	—	—	—	—	—	—	—
EPS Growth YoY (%)	38.6% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	-13.7% Weak ↑ Weak Improving Year-over-year change in earnings per share Optimal: > 10%	-14.6% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	-32.6% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—	—	—	—
Net Income Growth YoY (%)	36.2% Excellent ↑ Excellent Improving Year-over-year change in net income	-20.1% Weak ↑ Weak Improving Year-over-year change in net income	-27.8% Weak ↑ Weak Improving Year-over-year change in net income	-43.5% Weak ↑ Weak Improving Year-over-year change in net income	-26.7% Weak ↑ Weak Improving Year-over-year change in net income	-50.6% Weak ↓ Weak Declining Year-over-year change in net income	-120.7% Weak ↓ Weak Declining Year-over-year change in net income	-7.0% Weak ↑ Weak Improving Year-over-year change in net income	-6.4% Weak ↑ Weak Improving Year-over-year change in net income	-122.8% Weak Weak Year-over-year change in net income	-103.5% Weak Weak Year-over-year change in net income	—	—
FCF Growth YoY (%)	29.7% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	16.2% Good ↑ Good Improving Year-over-year change in free cash flow	-11.2% Weak Weak Year-over-year change in free cash flow	0.1% Caution Caution Year-over-year change in free cash flow	—	—	—	—	—	—	—	—	—
Revenue CAGR 3Y (%)	133.7% Excellent Excellent Compound annual revenue growth over 3 years	—	—	—	—	—	—	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Operating Margin (%) (%)	-26.1% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-274%)	-72.7% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-585%)	-85.7% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-671%)	-359.3% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2496%)	—	—	—	—	—	—	—	—	—
Effective Tax Rate (%) (%)	0.3% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.4% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—	—	—	—	—	—	—
Profit Margin (%) (%)	-28.7% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-339%)	-74.5% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-721%)	-88.4% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-837%)	-374.0% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-3217%)	—	—	—	—	—	—	—	—	—
FCF Margin (%) (%)	-14.7% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-33.4% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-53.8% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-234.3% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	—	—	—	—	—	—	—
FCF / Net Income (x)	0.51x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.45x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.61x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.63x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.83x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.76x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	0.68x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.97x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.91x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.79x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.61x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	0.77x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Return on Invested Capital (%)	-80.7% Weak → Weak Stable Return earned on debt + equity capital invested Optimal: > 10%	-118.1% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-63.1% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-69.7% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-152.2% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-48.3% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-27.1% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-569.4% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-91.8% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-70.1% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-15.6% Weak Weak Return earned on debt + equity capital invested Optimal: > 10%	139.9% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	—
Return on Capital (%) (%)	-24.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-49.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-39.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-54.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-142.1% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-53.3% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-30.5% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-213.6% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-76.4% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-72.1% Weak Weak Operating profit relative to total assets Optimal: > 10%	-18.7% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	-207.5% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1483%)	—	-125.3% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-935%)	-170.8% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1239%)	—	-90.4% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-703%)	-38.2% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-355%)	—	-173.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1254%)	-126.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-941%)	-26.3% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-275%)	187.4% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+1149%)	—

⚖️ Is the balance sheet risky? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Debt to Equity (x)	1.33x Caution ↓ Caution Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+122%)	3.17x Weak ↑ Weak Improving Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+428%)	0.93x Fair ↓ Fair Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+55%)	0.86x Fair ↓ Fair Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+43%)	3.14x Weak ↑ Weak Improving Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+423%)	0.42x Good ↓ Good Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-29%)	0.10x Excellent ↓ Excellent Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-84%)	3.86x Weak ↑ Weak Improving Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+543%)	0.40x Good Good Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-34%)	0.44x Good Good Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-27%)	—	—	—
Interest Coverage (x)	-10.47x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-13.00x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-11.57x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-23.39x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-26.96x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-47.27x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-52.23x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-42.55x Weak Weak Operating income divided by interest expense Optimal: > 5x	-31.39x Weak Weak Operating income divided by interest expense Optimal: > 5x	—	—	—	—
Net Debt (USD)	$-205.19M	$-134.64M	$-208.12M	$-106.58M	$-37.38M	$-135.55M	$-202.63M	$3.62M	$6.66M	$9.47M	—	—	—
Debt / EBITDA (x)	-0.71x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.65x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.77x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.53x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.39x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.49x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.26x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.11x Excellent ↑ Excellent Improving Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.25x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.34x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	—	—	—

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Revenue per Share (USD)	$12.83	$8.05	$5.96	$1.23	—	—	—	—	—	—	—	—	—
Basic EPS, GAAP (USD)	$-3.68	$-5.99	$-5.27	$-4.60	$-3.47	—	—	—	—	—	—	—	—
Free Cash Flow per Share (USD)	$-1.89	$-2.69	$-3.21	$-2.88	$-2.89	—	—	—	—	—	—	—	—
Book Value per Share (USD)	$1.74	$1.17	$4.03	$2.52	$0.41	$3.04	$4.84	$0.03	$0.66	$1.13	$2.43	—	—
Tangible Book Value per Share (USD)	$0.70	$-0.04	$2.65	$0.91	$0.41	$3.04	$4.84	$0.03	$0.66	$1.13	$2.43	—	—
Basic Weighted Avg Shares (shares)	49.75M	47.91M	45.43M	40.66M	37.62M	—	—	—	—	—	—	—	—

🏦 How resilient is the balance sheet? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Working Capital (USD)	$210.15M	$254.96M	$365.41M	$149.08M	$63.45M	$160.59M	$195.88M	$4.39M	$23.12M	$30.83M	$46.40M	—	—
LT Debt (USD)	$117.75M	$180.71M	$178.07M	$94.26M	$49.09M	$48.32M	$17.33M	$3.62M	$6.66M	$9.47M	—	—	—
Total Equity (USD)	$88.30M	$57.02M	$190.98M	$109.56M	$15.63M	$113.79M	$178.72M	$937.92K	$16.72M	$21.57M	$46.44M	$-3.20M	$-2.03M

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗
Sales/Revenue/Turnover (USD)	$638.50M	$385.69M	$270.60M	$50.04M	—	—	—	—	—	—	—	—	—
Depreciation Expense (USD)	$503.00K	$532.00K	$459.00K	$263.44K	$76.35K	$23.86K	$37.33K	$48.94K	$42.56K	$20.48K	$3.54K	—	—
Net Income, GAAP (USD)	$-183.17M	$-287.22M	$-239.24M	$-187.13M	$-130.40M	$-102.90M	$-68.35M	$-30.97M	$-28.94M	$-27.20M	$-12.21M	$-6.00M	—
Operating Cash Flow (USD)	$-93.41M	$-128.41M	$-145.08M	$-116.51M	$-108.23M	$-78.46M	$-46.38M	$-30.05M	$-26.47M	$-21.28M	$-7.44M	$-4.60M	—

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bar_chart Data from SEC EDGAR XBRL filings

Synced 4 days ago 13 years · 49 quarters

Axsome Therapeutics, Inc.

Analytical Summary

13-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

Statement lens

Benchmark Lens

Signals

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