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IONIS PHARMACEUTICALS INC

IONS

$38.77 ▼ -1.34 (-3.35%) at close

19 Visible periods

31 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

IONIS PHARMACEUTICALS INC faces fundamental challenges with weakness in Return on Common Equity (%) and Profit Margin (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $6.2B

Dividend Yield —

Revenue Growth 33.8% ↗

Op. Margin -40.4% ↗

ROIC -16.7% ↗

FCF / Share $-2.00 ↗

Trailing P/E —

Price / Book 13.0x

FCF Yield —

Debt / Equity 3.71

info Valuation on last close. End-of-day price, Nov 5, 2026.

19-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$943.71M

↑ +33.8% —

Net Income Profit after all expenses

$-381.39M

↑ +16.0% —

Operating Margin Operating profit as % of sales

-40.4%

↑ +40.0% 6th

FCF / Share Free cash flow per share

$-2.00

↑ +45.3% —

Long-Term Debt Long-term obligations

$1.81B

↑ +44.6% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Debt to EquityDebt to Equity is concerning (bottom quartile)
Operating Margin (%)Operating Margin (%) is in the bottom quartile
Profit Margin (%)Profit Margin (%) is in the bottom quartile
Return on Common Equity (%)Return on Common Equity (%) is in the bottom quartile

Health Breakdown

Profitability ↓

Returns ↓

Financial Health →

Cash Quality

Financial view

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📈 Is growth accelerating? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Revenue Growth YoY (%)	33.8% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+323%)	-10.5% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-231%)	34.1% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+326%)	-27.5% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-444%)	11.1% Good ↓ Good Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+39%)	-35.0% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-538%)	87.2% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+990%)	16.6% Good ↓ Good Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+108%)	48.3% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+504%)	22.2% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+177%)	32.5% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+306%)	45.4% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+468%)	44.3% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+454%)	3.0% Caution ↑ Caution Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-63%)	-8.7% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-208%)	-10.8% Weak Weak Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-235%)	13.4% Good Good Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+68%)	—	—
EPS Growth YoY (%)	21.7% Good ↑ Good Improving Year-over-year change in earnings per share Optimal: > 10%	-18.8% Weak ↑ Weak Improving Year-over-year change in earnings per share Optimal: > 10%	-34.7% Weak ↑ Weak Improving Year-over-year change in earnings per share Optimal: > 10%	-850.0% Weak ↓ Weak Declining Year-over-year change in earnings per share Optimal: > 10%	93.7% Excellent ↓ Excellent Declining Year-over-year change in earnings per share Optimal: > 10%	N/M	1.4% Caution Caution Year-over-year change in earnings per share Optimal: > 10%	1293.3% Excellent Excellent Year-over-year change in earnings per share Optimal: > 10%	N/M	—	—	—	—	—	-37.1% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	N/M	N/M	—	—
Net Income Growth YoY (%)	16.0% Good ↑ Good Improving Year-over-year change in net income	-23.9% Weak ↑ Weak Improving Year-over-year change in net income	-35.8% Weak ↑ Weak Improving Year-over-year change in net income	-843.2% Weak ↓ Weak Declining Year-over-year change in net income	93.6% Excellent ↓ Excellent Declining Year-over-year change in net income	N/M	7.5% Fair ↓ Fair Declining Year-over-year change in net income	79015.9% Excellent ↑ Excellent Improving Year-over-year change in net income	N/M	2.0% Caution ↑ Caution Improving Year-over-year change in net income	-126.4% Weak ↓ Weak Declining Year-over-year change in net income	35.7% Excellent ↑ Excellent Improving Year-over-year change in net income	7.4% Fair ↑ Fair Improving Year-over-year change in net income	22.8% Good Good Year-over-year change in net income	-38.4% Weak Weak Year-over-year change in net income	N/M	N/M	—	—
FCF Growth YoY (%)	45.3% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	-57.9% Weak ↓ Weak Declining Year-over-year change in free cash flow	-13.1% Weak ↓ Weak Declining Year-over-year change in free cash flow	N/M	2316.5% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	-99.8% Weak ↓ Weak Declining Year-over-year change in free cash flow	-49.5% Weak Weak Year-over-year change in free cash flow	296.2% Excellent Excellent Year-over-year change in free cash flow	N/M	—	—	—	—	—	-58.1% Weak Weak Year-over-year change in free cash flow	37.6% Excellent Excellent Year-over-year change in free cash flow	N/M	—	—
Revenue CAGR 3Y (%)	17.1% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	-4.5% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	2.6% Caution ↑ Caution Improving Compound annual revenue growth over 3 years	-19.4% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	10.6% Good ↓ Good Declining Compound annual revenue growth over 3 years	12.4% Good ↓ Good Declining Compound annual revenue growth over 3 years	48.0% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	28.3% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	33.9% Excellent → Excellent Stable Compound annual revenue growth over 3 years	33.0% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	40.6% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	29.3% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	10.7% Good ↑ Good Improving Compound annual revenue growth over 3 years	-5.7% Weak Weak Compound annual revenue growth over 3 years	-2.6% Weak Weak Compound annual revenue growth over 3 years	—	—	—	—
Revenue CAGR 5Y (%)	5.3% Fair ↑ Fair Improving Compound annual revenue growth over 5 years	-8.9% Weak ↓ Weak Declining Compound annual revenue growth over 5 years	5.6% Fair ↓ Fair Declining Compound annual revenue growth over 5 years	2.7% Caution ↓ Caution Declining Compound annual revenue growth over 5 years	18.5% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	20.8% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	39.3% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	32.4% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	38.2% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	28.5% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	21.2% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	12.0% Good Good Compound annual revenue growth over 5 years	6.6% Fair Fair Compound annual revenue growth over 5 years	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Operating Margin (%) (%)	-40.4% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-370%)	-67.4% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-549%)	-44.9% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-399%)	-69.8% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-566%)	-3.7% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-125%)	-23.6% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-257%)	32.6% Excellent ↑ Excellent Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+117%)	-10.2% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-168%)	6.0% Caution ↑ Caution Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-60%)	-13.4% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-189%)	-26.7% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-278%)	-22.3% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-249%)	-35.1% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-334%)	-67.5% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-550%)	-71.8% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-578%)	-44.6% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-397%)	-22.6% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-251%)	-12.2% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-181%)	—
Effective Tax Rate (%) (%)	-0.5% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	1.3% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-9.7% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-4.5% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	1.9% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-256.5% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—	-0.4% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	28.3% Caution ↑ Caution Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	8.9% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	-0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.2% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—
Profit Margin (%) (%)	-40.4% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-437%)	-64.4% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-636%)	-46.5% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-488%)	-45.9% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-483%)	-3.5% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-129%)	-60.9% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-608%)	26.2% Excellent ↑ Excellent Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+118%)	45.6% Excellent ↑ Excellent Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+280%)	0.1% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-99%)	-25.0% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-308%)	-31.1% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-359%)	-18.2% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-252%)	-41.2% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-443%)	-64.2% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-635%)	-85.6% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-813%)	-56.5% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-571%)	—	-17.0% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-241%)	—
FCF Margin (%) (%)	-33.9% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-77.5% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-42.1% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-49.4% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	2.3% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	0.1% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	28.0% Excellent ↓ Excellent Declining Free cash flow as a percentage of revenue Optimal: > 10%	98.3% Excellent ↑ Excellent Improving Free cash flow as a percentage of revenue Optimal: > 10%	27.1% Excellent Excellent Free cash flow as a percentage of revenue Optimal: > 10%	-34.4% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	—	—	-123.3% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-70.8% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-100.2% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	185.1% Excellent Excellent Free cash flow as a percentage of revenue Optimal: > 10%	—
FCF / Net Income (x)	0.84x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.20x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	0.90x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	1.08x Fair ↑ Fair Improving Free cash flow relative to reported net income Optimal: > 1x	-0.66x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	-0.00x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	1.07x Fair ↓ Fair Declining Free cash flow relative to reported net income Optimal: > 1x	2.15x Excellent ↓ Excellent Declining Free cash flow relative to reported net income Optimal: > 1x	402.85x Excellent Excellent Free cash flow relative to reported net income Optimal: > 1x	1.38x Good Good Free cash flow relative to reported net income Optimal: > 1x	—	—	—	—	1.44x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	1.25x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	-0.79x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	-10.92x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Return on Invested Capital (%)	-16.7% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-25.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-22.9% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-24.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-3.8% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-82.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	19.6% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	-4.6% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	8.7% Fair ↑ Fair Improving Return earned on debt + equity capital invested Optimal: > 10%	-36.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-37.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-13.3% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-12.4% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-29.8% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-41.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-19.8% Weak Weak Return earned on debt + equity capital invested Optimal: > 10%	-7.5% Weak Weak Return earned on debt + equity capital invested Optimal: > 10%	—	—
Return on Capital (%) (%)	-10.8% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-15.8% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-11.8% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-16.2% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-1.2% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-7.2% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	11.3% Good ↑ Good Improving Operating profit relative to total assets Optimal: > 10%	-2.3% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	2.3% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-5.1% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-8.0% Weak → Weak Stable Operating profit relative to total assets Optimal: > 10%	-5.0% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-6.1% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-12.6% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-14.7% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-8.8% Weak Weak Operating profit relative to total assets Optimal: > 10%	-4.2% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	-78.0% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-620%)	-77.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-614%)	-94.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-731%)	-47.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-414%)	-3.7% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-125%)	-59.8% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-498%)	20.0% Good ↑ Good Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+33%)	26.1% Excellent ↑ Excellent Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+74%)	0.1% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-99%)	-86.9% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-680%)	-44.0% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-393%)	-15.1% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-201%)	-16.0% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-207%)	-35.8% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-339%)	-49.5% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-430%)	-25.0% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-267%)	53.2% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+254%)	—	—

⚖️ Is the balance sheet risky? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Debt to Equity (x)	3.71x Weak ↑ Weak Improving Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+518%)	2.13x Weak ↓ Weak Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+255%)	3.38x Weak Weak Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+464%)	2.08x Weak Weak Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Above avg (+247%)	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Interest Coverage (x)	-22.11x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-27.96x Weak → Weak Stable Operating income divided by interest expense Optimal: > 5x	-27.94x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-50.50x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-3.23x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-18.09x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	7.50x Good ↑ Good Improving Operating income divided by interest expense Optimal: > 5x	-1.37x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	0.69x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-1.19x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-2.06x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-2.15x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-2.67x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-3.26x Weak → Weak Stable Operating income divided by interest expense Optimal: > 5x	-4.25x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-3.65x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-2.17x Weak Weak Operating income divided by interest expense Optimal: > 5x	-1.11x Weak Weak Operating income divided by interest expense Optimal: > 5x	—
Net Debt (USD)	$1.44B	$1.01B	$909.09M	$917.76M	$-869.19M	$-397.66M	$-683.29M	$-278.82M	$-129.63M	$-84.69M	$-128.80M	$-143.00M	$-159.97M	$-124.48M	$-65.48M	$-70.05M	$-105.25M	$-223.99M	$-138.61M
Debt / EBITDA (x)	-4.88x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-2.69x Excellent ↑ Excellent Improving Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-3.81x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-3.02x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Revenue per Share (USD)	$5.90	$4.72	$5.50	$4.14	$5.75	$5.22	$8.02	$4.53	$4.15	$2.87	—	—	—	$1.01	$0.99	$1.09	$1.24	$1.13	—
Basic EPS, GAAP (USD)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$2.12	$2.09	$0.15	$-0.72	—	—	—	—	$-0.85	$-0.62	$1.58	$-0.19	—
Free Cash Flow per Share (USD)	$-2.00	$-3.65	$-2.31	$-2.05	$0.13	$0.01	$2.25	$4.45	$1.12	$-0.99	—	—	—	—	$-1.23	$-0.77	$-1.24	$2.10	—
Book Value per Share (USD)	$2.99	$3.73	$2.68	$4.03	$5.47	$5.30	$10.48	$7.60	$2.25	$0.82	$1.67	$2.18	$3.25	$1.80	$1.71	$2.46	$2.95	—	—
Tangible Book Value per Share (USD)	$2.99	$3.73	$2.68	$4.03	$5.47	$5.30	$10.48	$7.60	$2.25	$0.82	$1.67	$2.18	$3.25	$1.80	$1.71	$2.46	$2.95	—	—
Basic Weighted Avg Shares (shares)	160.01M	149.51M	143.19M	141.85M	141.02M	139.61M	140.00M	132.32M	124.02M	120.93M	—	—	—	100.58M	99.66M	99.14M	98.11M	94.57M	—

🏦 How resilient is the balance sheet? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Working Capital (USD)	$2.21B	$2.31B	$2.19B	$1.89B	$2.10B	$1.53B	$2.45B	$1.93B	$925.12M	$664.15M	$688.13M	$721.26M	$637.70M	$349.12M	$284.03M	$377.25M	$484.68M	—	—
LT Debt (USD)	$1.81B	$1.25B	$1.31B	$1.19B	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Total Equity (USD)	$489.09M	$588.35M	$386.69M	$572.89M	$771.74M	$743.28M	$1.47B	$1.05B	$281.01M	$99.56M	$200.79M	$257.78M	$378.39M	$182.77M	$171.43M	$244.54M	$291.72M	—	—

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗	FY 2007 Dec 31, 2007 10-K ↗
Sales/Revenue/Turnover (USD)	$943.71M	$705.14M	$787.65M	$587.37M	$810.46M	$729.26M	$1.12B	$599.67M	$514.18M	$346.62M	$283.70M	$214.16M	$147.28M	$102.05M	$99.09M	$108.47M	$121.60M	$107.19M	—
Depreciation Expense (USD)	$10.01M	$9.61M	$10.29M	$14.33M	$15.49M	$13.37M	$12.54M	$10.71M	$6.71M	$7.48M	$6.98M	$6.38M	$6.59M	$7.07M	$6.59M	$4.84M	$3.94M	$2.87M	—
Net Income, GAAP (USD)	$-381.39M	$-453.90M	$-366.29M	$-269.72M	$-28.60M	$-444.26M	$294.15M	$273.74M	$346.00K	$-86.56M	$-88.28M	$-38.98M	$-60.64M	$-65.48M	$-84.80M	$-61.25M	$155.07M	$-18.17M	—
Operating Cash Flow (USD)	$-268.58M	$-500.95M	$-307.51M	$-274.37M	$30.80M	$35.89M	$345.63M	$602.89M	$174.15M	$-112.11M	—	—	—	—	$-114.80M	$-63.59M	$-108.44M	$212.03M	—

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bar_chart Data from SEC EDGAR XBRL filings

Synced 4 days ago 19 years · 72 quarters

IONIS PHARMACEUTICALS INC

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