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Karyopharm Therapeutics Inc.

KPTI

$0.07 ▼ -0.02 (-21.45%) at close

17 Visible periods

28 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Weak

Moderately Bearish

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Analytical Summary

Karyopharm Therapeutics Inc. faces fundamental challenges with weakness in Profit Margin (%) and Operating Margin (%). Investors should exercise caution and monitor for improvement in key metrics.

Market Cap —

Dividend Yield —

Revenue Growth 0.6% ↗

Op. Margin -62.1% ↗

ROIC 31.0% ↘

FCF / Share None

Trailing P/E —

Price / Book —

FCF Yield —

Debt / Equity —

info Valuation on last close. End-of-day price, Nov 5, 2026.

17-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$146.07M

↑ +0.6% —

Net Income Profit after all expenses

$-196.04M

↓ -156.5% —

Operating Margin Operating profit as % of sales

-62.1%

↑ +24.5% 4th

FCF / Share Free cash flow per share

$-0.81

↑ +55.6% —

trending_up

Bullish Indicators

Return on Common Equity (%)Return on Common Equity (%) is in the top quartile

warning

Bearish Risks

Operating Margin (%)Operating Margin (%) is in the bottom quartile
Profit Margin (%)Profit Margin (%) is in the bottom quartile

Health Breakdown

Profitability ↓

Returns

Financial Health ↓

Cash Quality ↓

Financial view

Statement lens

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Cadence

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📈 Is growth accelerating? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Revenue Growth YoY (%)	0.6% Caution ↑ Caution Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-93%)	-0.5% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-107%)	-7.0% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-188%)	-25.1% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-414%)	94.1% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1077%)	164.3% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1954%)	34.8% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+335%)	1790.1% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+22276%)	942.2% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+11678%)	-38.4% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-580%)	9.2% Fair ↓ Fair Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+15%)	-81.9% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-1124%)	99.7% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1146%)	317.1% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+3864%)	—	—	—
EPS Growth YoY (%)	-90.5% Weak ↑ Weak Improving Year-over-year change in earnings per share Optimal: > 10%	-652.8% Weak ↓ Weak Declining Year-over-year change in earnings per share Optimal: > 10%	38.1% Excellent Excellent Year-over-year change in earnings per share Optimal: > 10%	-22.4% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—	—	—	—	—	—	—	—
Net Income Growth YoY (%)	-156.5% Weak ↓ Weak Declining Year-over-year change in net income	46.6% Excellent ↑ Excellent Improving Year-over-year change in net income	13.4% Fair ↑ Fair Improving Year-over-year change in net income	-33.2% Weak ↓ Weak Declining Year-over-year change in net income	36.8% Excellent ↑ Excellent Improving Year-over-year change in net income	1.7% Caution ↑ Caution Improving Year-over-year change in net income	-11.9% Weak ↑ Weak Improving Year-over-year change in net income	-38.3% Weak ↓ Weak Declining Year-over-year change in net income	-17.7% Weak ↑ Weak Improving Year-over-year change in net income	7.3% Fair ↑ Fair Improving Year-over-year change in net income	-56.0% Weak ↑ Weak Improving Year-over-year change in net income	-21.1% Weak ↑ Weak Improving Year-over-year change in net income	-293.8% Weak ↑ Weak Improving Year-over-year change in net income	-54.1% Weak ↑ Weak Improving Year-over-year change in net income	-359.5% Weak Weak Year-over-year change in net income	-1153.6% Weak Weak Year-over-year change in net income	—
FCF Growth YoY (%)	—	—	55.6% Excellent Excellent Year-over-year change in free cash flow	-28.1% Weak Weak Year-over-year change in free cash flow	—	—	—	—	—	—	—	—	—	—	—	—	—
Revenue CAGR 3Y (%)	-2.4% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	-11.5% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	10.6% Good ↓ Good Declining Compound annual revenue growth over 3 years	56.6% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	90.5% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	306.8% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	542.8% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	395.1% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	91.4% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	-50.5% Weak ↓ Weak Declining Compound annual revenue growth over 3 years	-26.7% Weak Weak Compound annual revenue growth over 3 years	14.6% Good Good Compound annual revenue growth over 3 years	—	—	—	—	—
Revenue CAGR 5Y (%)	6.2% Fair ↓ Fair Declining Compound annual revenue growth over 5 years	28.9% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	36.9% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	150.1% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	323.5% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	236.6% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	182.1% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	88.8% Excellent ↑ Excellent Improving Compound annual revenue growth over 5 years	20.4% Excellent Excellent Compound annual revenue growth over 5 years	0.3% Weak Weak Compound annual revenue growth over 5 years	—	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Operating Margin (%) (%)	-62.1% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-514%)	-82.2% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-648%)	-88.7% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-691%)	-90.5% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-704%)	-46.8% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-412%)	-159.0% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1160%)	-462.9% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-3186%)	—	—	—	—	—	—	—	—	—	—
Effective Tax Rate (%) (%)	-0.0% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.1% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.2% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.2% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.2% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.2% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.0% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.0% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.1% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—	—	—	—
Profit Margin (%) (%)	-134.2% Weak ↓ Weak Declining Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1218%)	-52.6% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-538%)	-98.0% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-917%)	-105.2% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-977%)	-59.1% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-593%)	-181.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1613%)	-488.1% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-4167%)	—	—	—	—	—	—	—	—	—	—
FCF Margin (%) (%)	-51.6% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-87.9% Weak ↓ Weak Declining Free cash flow as a percentage of revenue Optimal: > 10%	-63.5% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-95.3% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-51.2% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-148.4% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-467.1% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	—	—	—	—	—	—	—	—
FCF / Net Income (x)	0.38x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	1.67x Excellent ↑ Excellent Improving Free cash flow relative to reported net income Optimal: > 1x	0.65x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.91x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.86x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.82x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.96x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.91x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	0.57x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	—	—	—	—	—	—	—	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Return on Invested Capital (%)	31.0% Excellent ↓ Excellent Declining Return earned on debt + equity capital invested Optimal: > 10%	64.3% Excellent ↓ Excellent Declining Return earned on debt + equity capital invested Optimal: > 10%	95.3% Excellent ↓ Excellent Declining Return earned on debt + equity capital invested Optimal: > 10%	855.7% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	123.6% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	-340.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-380.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-98.2% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-100.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-68.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-47.4% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-29.0% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-31.8% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	45.0% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	64.4% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	—	—
Return on Capital (%) (%)	-83.7% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-72.6% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-53.9% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-39.7% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-32.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-54.9% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-64.2% Weak → Weak Stable Operating profit relative to total assets Optimal: > 10%	-52.7% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-72.4% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-61.4% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-55.3% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-34.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-39.4% Weak Weak Operating profit relative to total assets Optimal: > 10%	-1212.1% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—	—
Return on Common Equity (%) (%)	66.9% Excellent ↓ Excellent Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+346%)	41.1% Excellent ↓ Excellent Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+174%)	105.1% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+600%)	—	155.7% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+938%)	—	—	-97.4% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-749%)	-99.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-764%)	-67.5% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-550%)	-59.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-497%)	-36.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-344%)	-40.4% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-369%)	57.0% Excellent ↓ Excellent Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+280%)	81.5% Excellent ↓ Excellent Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+443%)	94.4% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+530%)	100.0% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+567%)

⚖️ Is the balance sheet risky? 2 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Interest Coverage (x)	-8.50x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-6.98x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-5.44x Weak → Weak Stable Operating income divided by interest expense Optimal: > 5x	-5.69x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-3.77x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-6.33x Weak ↑ Weak Improving Operating income divided by interest expense Optimal: > 5x	-12.10x Weak Weak Operating income divided by interest expense Optimal: > 5x	-72.16x Weak Weak Operating income divided by interest expense Optimal: > 5x	—	—	—	-75846.00x Weak Weak Operating income divided by interest expense Optimal: > 5x	-331.84x Weak Weak Operating income divided by interest expense Optimal: > 5x	—	—	—	—
Net Debt (USD)	$-60.54M	$-62.48M	$-52.23M	$-135.19M	$-190.46M	$-85.92M	$-128.86M	$-118.02M	$-69.00M	$-49.66M	$-58.36M	$-150.61M	$-155.97M	$-391.00K	$-6.51M	$-3.44M	—

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Revenue per Share (USD)	—	—	$1.28	$1.92	$2.79	—	—	—	—	—	—	—	—	—	—	—	—
Basic EPS, GAAP (USD)	$-17.93	$-9.41	$-1.25	$-2.02	$-1.65	—	—	—	—	—	—	—	—	—	—	—	—
Free Cash Flow per Share (USD)	—	—	$-0.81	$-1.83	$-1.43	—	—	—	—	—	—	—	—	—	—	—	—
Book Value per Share (USD)	$-16.00	$-22.11	$-1.19	$-0.15	$-1.05	$0.68	$0.76	$3.01	$2.61	$3.87	$5.53	$6.32	$5.24	$-13.13	—	—	—
Tangible Book Value per Share (USD)	$-16.00	$-22.11	$-1.19	$-0.15	$-1.05	$0.68	$0.76	$3.01	$2.61	$3.87	$5.53	$6.32	$5.24	$-13.13	—	—	—
Basic Weighted Avg Shares (shares)	10,935	8,125	114.22M	81.87M	75.22M	—	—	—	—	—	—	—	—	—	—	—	—

🏦 How resilient is the balance sheet? 2 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Working Capital (USD)	$11.09M	$64.20M	$164.44M	$284.25M	$201.89M	$216.33M	$232.22M	$287.71M	$98.96M	$115.16M	$162.47M	$195.45M	$154.66M	$-976.00K	—	—	—
Total Equity (USD)	$-292.93M	$-186.02M	$-136.21M	$-16.66M	$-79.67M	$50.55M	$49.77M	$183.17M	$129.46M	$162.24M	$198.37M	$206.79M	$154.93M	$-27.88M	$-12.65M	$-2.38M	$-179.00K

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗
Sales/Revenue/Turnover (USD)	$146.07M	$145.24M	$146.03M	$157.07M	$209.82M	$108.08M	$40.89M	$30.34M	$1.60M	$154.00K	$250.00K	$229.00K	$1.27M	$634.00K	$152.00K	—	—
Depreciation Expense (USD)	$296.00K	$340.00K	$530.00K	$621.00K	$789.00K	$972.00K	$974.00K	—	—	—	—	—	$350.00K	$122.00K	$83.00K	—	—
Net Income, GAAP (USD)	$-196.04M	$-76.42M	$-143.10M	$-165.29M	$-124.09M	$-196.27M	$-199.59M	$-178.41M	$-128.98M	$-109.58M	$-118.18M	$-75.78M	$-62.57M	$-15.89M	$-10.31M	$-2.24M	$-179.00K
Operating Cash Flow (USD)	$-75.37M	$-127.49M	$-92.72M	$-149.55M	$-107.12M	$-160.23M	$-190.82M	$-159.12M	$-73.72M	—	—	—	—	—	—	—	—

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bar_chart Data from SEC EDGAR XBRL filings

Synced 4 days ago 17 years · 58 quarters

Karyopharm Therapeutics Inc.

Analytical Summary

17-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

Statement lens

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