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Spero Therapeutics, Inc.

SPRO

$1.36 ▲ +0.22 (+19.30%) at close

12 Visible periods

27 Metrics

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Fair

Bullish

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Analytical Summary

Spero Therapeutics, Inc. shows strong fundamentals with top-quartile Return on Common Equity (%). The company's metrics support a bullish outlook for growth-oriented investors.

Market Cap $76.2M

Dividend Yield —

Revenue Growth 39.2% ↗

Op. Margin 9.5% ↗

ROIC 10.4% ↗

FCF / Share $-0.23 ↗

Trailing P/E 9.1x

Price / Book 1.3x

FCF Yield —

Debt / Equity —

info Valuation on last close. End-of-day price, Sep 22, 2026.

12-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$66.80M

↑ +39.2% —

Net Income Profit after all expenses

$8.57M

↑ +112.5% —

Operating Margin Operating profit as % of sales

9.5%

↑ +106.2% 55th

FCF / Share Free cash flow per share

$-0.23

↑ +48.1% —

trending_up

Bullish Indicators

Return on Common Equity (%)Return on Common Equity (%) is in the top quartile

warning

Bearish Risks

No bearish risks detected.

Health Breakdown

Profitability ↑

Returns

Cash Quality

Financial view

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📈 Is growth accelerating? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Revenue Growth YoY (%)	39.2% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+390%)	-53.8% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-772%)	94.0% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1074%)	193.1% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+2314%)	95.7% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1096%)	-48.6% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-707%)	357.6% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+4370%)	100.4% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1155%)	—	—	—	—
EPS Growth YoY (%)	N/M	N/M	N/M	57.7% Excellent Excellent Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—	—	—
Net Income Growth YoY (%)	N/M	N/M	N/M	48.3% Excellent ↑ Excellent Improving Year-over-year change in net income	-14.6% Weak ↑ Weak Improving Year-over-year change in net income	-28.6% Weak ↑ Weak Improving Year-over-year change in net income	-46.2% Weak ↑ Weak Improving Year-over-year change in net income	-7.5% Weak ↑ Weak Improving Year-over-year change in net income	-52.0% Weak Weak Year-over-year change in net income	-151.0% Weak Weak Year-over-year change in net income	—	—
FCF Growth YoY (%)	48.1% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	30.7% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	-204.4% Weak Weak Year-over-year change in free cash flow	90.1% Excellent Excellent Year-over-year change in free cash flow	—	—	—	—	—	—	—	—
Revenue CAGR 3Y (%)	7.7% Fair ↓ Fair Declining Compound annual revenue growth over 3 years	38.0% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	123.2% Excellent ↑ Excellent Improving Compound annual revenue growth over 3 years	43.4% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	66.3% Excellent Excellent Compound annual revenue growth over 3 years	67.7% Excellent Excellent Compound annual revenue growth over 3 years	—	—	—	—	—	—
Revenue CAGR 5Y (%)	48.2% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	21.5% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	92.1% Excellent Excellent Compound annual revenue growth over 5 years	93.4% Excellent Excellent Compound annual revenue growth over 5 years	—	—	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Operating Margin (%) (%)	9.5% Caution ↑ Caution Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-37%)	-152.9% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1119%)	20.7% Good ↑ Good Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+38%)	-78.9% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-626%)	-481.9% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-3312%)	—	-348.4% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2422%)	—	—	—	—	—
Effective Tax Rate (%) (%)	3.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	10.2% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent → Excellent Stable Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—	—	—
Profit Margin (%) (%)	12.8% Fair ↑ Fair Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+7%)	-142.9% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1291%)	22.0% Excellent ↑ Excellent Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Above avg (+83%)	-86.7% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-823%)	-491.7% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-4197%)	—	-335.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2897%)	—	—	—	—	—
FCF Margin (%) (%)	-18.9% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-48.9% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-31.8% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-14.4% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-352.5% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	-277.4% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	—	—	—
FCF / Net Income (x)	-1.47x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.34x Weak ↑ Weak Improving Free cash flow relative to reported net income Optimal: > 1x	-1.45x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.17x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.72x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.10x Fair ↑ Fair Improving Free cash flow relative to reported net income Optimal: > 1x	0.83x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.01x Fair Fair Free cash flow relative to reported net income Optimal: > 1x	1.01x Fair Fair Free cash flow relative to reported net income Optimal: > 1x	—	—	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Return on Invested Capital (%)	10.4% Good ↑ Good Improving Return earned on debt + equity capital invested Optimal: > 10%	-159.1% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	18.0% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	-55.6% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-99.6% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-59.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-67.0% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-29.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-39.0% Weak Weak Return earned on debt + equity capital invested Optimal: > 10%	57.8% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	—	—
Return on Capital (%) (%)	9.2% Fair ↑ Fair Improving Operating profit relative to total assets Optimal: > 10%	-66.4% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	11.8% Good ↑ Good Improving Operating profit relative to total assets Optimal: > 10%	-33.8% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-51.4% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-51.6% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-59.6% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-33.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-44.6% Weak Weak Operating profit relative to total assets Optimal: > 10%	-241.2% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	14.5% Fair ↑ Fair Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: At sector avg	-148.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1091%)	21.3% Excellent ↑ Excellent Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+42%)	-61.1% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-508%)	-101.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-778%)	-59.3% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-495%)	-81.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-644%)	-36.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-340%)	-45.8% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-405%)	56.1% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+274%)	—	—

⚖️ Is the balance sheet risky? 1 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Net Debt (USD)	$-40.27M	$-52.89M	$-76.33M	$-109.11M	$-112.58M	$-85.21M	$-29.73M	$-34.08M	$-87.29M	$-10.31M	$-5.69M	$-256.00K

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Revenue per Share (USD)	$1.19	$0.89	$1.97	$1.42	$0.59	—	—	—	—	—	—	—
Basic EPS, GAAP (USD)	$0.15	$-1.27	$0.43	$-1.23	$-2.91	—	—	—	—	—	—	—
Free Cash Flow per Share (USD)	$-0.23	$-0.43	$-0.63	$-0.21	$-2.08	—	—	—	—	—	—	—
Book Value per Share (USD)	$1.05	$0.84	$2.02	$1.45	$2.73	$4.51	$3.89	$6.71	$5.89	—	—	—
Tangible Book Value per Share (USD)	$1.05	$0.84	$2.02	$1.45	$2.73	$4.51	$3.89	$6.71	$5.89	—	—	—
Basic Weighted Avg Shares (shares)	56.02M	54.04M	52.70M	37.59M	30.90M	—	—	—	—	—	—	—

🏦 How resilient is the balance sheet? 2 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Working Capital (USD)	$58.42M	$58.20M	$94.06M	$91.92M	$139.20M	$124.80M	$68.75M	$111.90M	$83.90M	$4.95M	—	—
Total Equity (USD)	$59.02M	$46.12M	$106.89M	$75.93M	$88.29M	$132.04M	$74.57M	$115.50M	$84.60M	$-45.44M	—	—

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗
Sales/Revenue/Turnover (USD)	$66.80M	$47.98M	$103.78M	$53.51M	$18.26M	$9.33M	$18.15M	$3.97M	$1.98M	—	—	—
Depreciation Expense (USD)	$0.00	$2.00K	$367.00K	$869.00K	$646.00K	$761.00K	$750.00K	$409.00K	$363.00K	$279.00K	$11.00K	—
Net Income, GAAP (USD)	$8.57M	$-68.57M	$22.81M	$-46.41M	$-89.76M	$-78.30M	$-60.90M	$-41.66M	$-38.74M	$-25.49M	$-10.15M	—
Operating Cash Flow (USD)	$-12.62M	$-23.44M	$-32.99M	$-7.73M	$-64.35M	$-85.87M	$-50.02M	$-39.62M	$-39.11M	—	—	—

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bar_chart Data from SEC EDGAR XBRL filings

Synced yesterday 12 years · 46 quarters

Spero Therapeutics, Inc.

Analytical Summary

12-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

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