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MADRIGAL PHARMACEUTICALS, INC.

MDGL

$509.67 ▼ -0.71 (-0.14%) at close

18 Visible periods

28 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

MADRIGAL PHARMACEUTICALS, INC. faces fundamental challenges with weakness in Return on Common Equity (%) and Profit Margin (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $11.4B

Dividend Yield —

Revenue Growth 432.1%

Op. Margin -31.3% ↗

ROIC -25.2% ↗

FCF / Share $-8.47 ↗

Trailing P/E —

Price / Book 19.3x

FCF Yield —

Debt / Equity 0.56

info Valuation on last close. End-of-day price, Aug 7, 2026.

18-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$958.40M

↑ +432.1% —

Net Income Profit after all expenses

$-288.28M

↑ +38.1% —

Operating Margin Operating profit as % of sales

-31.3%

↑ +88.7% 8th

FCF / Share Free cash flow per share

$-8.47

↑ +60.6% —

Long-Term Debt Long-term obligations

$339.88M

↑ +189.1% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Operating Margin (%)Operating Margin (%) is in the bottom quartile
Profit Margin (%)Profit Margin (%) is in the bottom quartile
Return on Common Equity (%)Return on Common Equity (%) is in the bottom quartile

Health Breakdown

Profitability ↑

Returns ↑

Financial Health

Cash Quality ↓

Financial view

Statement lens

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📈 Is growth accelerating? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Revenue Growth YoY (%)	432.1% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+5301%)	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
EPS Growth YoY (%)	41.3% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	-9.6% Weak ↑ Weak Improving Year-over-year change in earnings per share Optimal: > 10%	-16.0% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	-17.8% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—	—	—	—	—	-7.5% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	N/M	—	—
Net Income Growth YoY (%)	38.1% Excellent ↑ Excellent Improving Year-over-year change in net income	-24.7% Weak ↓ Weak Declining Year-over-year change in net income	-26.5% Weak ↑ Weak Improving Year-over-year change in net income	-22.1% Weak ↑ Weak Improving Year-over-year change in net income	-19.6% Weak ↑ Weak Improving Year-over-year change in net income	-140.9% Weak ↓ Weak Declining Year-over-year change in net income	-155.9% Weak ↓ Weak Declining Year-over-year change in net income	-5.3% Weak ↓ Weak Declining Year-over-year change in net income	-18.1% Weak ↓ Weak Declining Year-over-year change in net income	61.6% Excellent ↑ Excellent Improving Year-over-year change in net income	20.3% Good ↑ Good Improving Year-over-year change in net income	4.5% Caution ↑ Caution Improving Year-over-year change in net income	-43.6% Weak ↓ Weak Declining Year-over-year change in net income	-32.5% Weak Weak Year-over-year change in net income	-26.5% Weak Weak Year-over-year change in net income	N/M	—	—
FCF Growth YoY (%)	60.6% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	-23.3% Weak ↑ Weak Improving Year-over-year change in free cash flow	-32.7% Weak Weak Year-over-year change in free cash flow	-17.9% Weak Weak Year-over-year change in free cash flow	—	—	—	—	—	—	—	—	—	—	—	—	—	—

💰 Are margins durable? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Operating Margin (%) (%)	-31.3% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-309%)	-276.4% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1943%)	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Profit Margin (%) (%)	-30.1% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-351%)	-258.6% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2255%)	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
FCF Margin (%) (%)	-19.8% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-253.7% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
FCF / Net Income (x)	0.66x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.98x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.87x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.76x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.76x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.78x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.50x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.78x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.72x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	0.67x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	—	—	—	—	—	—	—	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Return on Invested Capital (%)	-25.2% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-45.1% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-57.7% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-86.8% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-97.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-68.0% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-18.0% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-6.7% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-13.9% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-54.7% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-106.0% Weak → Weak Stable Return earned on debt + equity capital invested Optimal: > 10%	-101.8% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-140.9% Weak → Weak Stable Return earned on debt + equity capital invested Optimal: > 10%	-64.1% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-242.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-124.2% Weak Weak Return earned on debt + equity capital invested Optimal: > 10%	251.5% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	—
Return on Capital (%) (%)	-23.8% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-47.8% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-59.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-81.0% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-88.7% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-72.0% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-21.5% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-8.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-16.7% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-61.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-99.1% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-83.4% Weak → Weak Stable Operating profit relative to total assets Optimal: > 10%	-92.0% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-59.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-107.3% Weak Weak Operating profit relative to total assets Optimal: > 10%	-68.2% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	-47.8% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-419%)	-61.8% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-512%)	-92.2% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-715%)	-149.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1098%)	-123.3% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-922%)	-84.3% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-662%)	-20.2% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-234%)	-6.9% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-146%)	-17.1% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-214%)	-72.5% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-583%)	-136.2% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1008%)	-132.3% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-982%)	-183.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1325%)	-83.6% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-658%)	—	-159.6% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-1164%)	—	—

⚖️ Is the balance sheet risky? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Debt to Equity (x)	0.56x Good ↑ Good Improving Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-6%)	0.16x Excellent ↓ Excellent Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-74%)	0.28x Excellent ↑ Excellent Improving Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-53%)	0.35x Good Good Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-41%)	0.00x Excellent Excellent Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-100%)	—	—	—	—	—	—	—	—	—	—	—	—	—
Interest Coverage (x)	—	—	-29.93x Weak Weak Operating income divided by interest expense Optimal: > 5x	-74.06x Weak Weak Operating income divided by interest expense Optimal: > 5x	—	—	—	—	—	-20.79x Weak Weak Operating income divided by interest expense Optimal: > 5x	—	—	—	—	—	—	—	—
Net Debt (USD)	$141.19M	$17.55M	$15.56M	$-261.87M	$-36.27M	$-54.00M	$-46.70M	$-57.38M	$-148.63M	$-19.14M	$-34.97M	$-46.02M	$-48.49M	$-81.51M	$-30.07M	$-31.31M	$-44.16M	$-52.05M
Debt / EBITDA (x)	-1.14x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.24x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.30x Excellent ↓ Excellent Declining Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.24x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	0.00x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	—	—	—	—	—	—	—	—	—	—	—	—	—

📊 What does each share earn? 6 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Revenue per Share (USD)	$42.72	$8.47	$0.00	$0.00	$0.00	—	—	—	—	—	—	—	—	—	—	—	—	—
Basic EPS, GAAP (USD)	$-12.85	$-21.90	$-19.99	$-17.23	$-14.63	—	—	—	—	—	—	—	—	—	$-1.00	$-0.93	$2.33	—
Free Cash Flow per Share (USD)	$-8.47	$-21.48	$-17.43	$-13.13	$-11.14	—	—	—	—	—	—	—	—	—	—	—	—	—
Book Value per Share (USD)	$26.39	$34.28	$20.39	$10.90	$11.47	$15.47	$27.00	$30.95	$12.81	$3.05	$0.37	$0.60	$0.58	$1.09	$0.30	$0.56	$0.74	—
Tangible Book Value per Share (USD)	$26.39	$34.28	$20.39	$10.90	$11.47	$15.47	$27.00	$30.95	$12.81	$3.05	$0.37	$0.60	$0.58	$1.09	$0.30	$0.56	$0.74	—
Basic Weighted Avg Shares (shares)	22.43M	21.27M	18.69M	17.14M	16.54M	—	—	—	—	—	—	—	—	—	47.20M	40.37M	33.89M	—

🏦 How resilient is the balance sheet? 3 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Working Capital (USD)	$935.48M	$863.65M	$518.73M	$245.47M	$194.85M	$238.61M	$415.07M	$476.76M	$181.96M	$36.41M	$49.99M	$68.46M	$60.03M	$77.90M	$25.14M	$34.78M	—	—
LT Debt (USD)	$339.88M	$117.57M	$115.48M	$69.67M	$0.00	—	—	—	—	—	—	—	—	—	—	—	—	—
Total Equity (USD)	$602.69M	$754.38M	$405.33M	$197.39M	$196.11M	$239.97M	$416.56M	$476.98M	$182.26M	$36.41M	$50.41M	$65.14M	$49.09M	$75.07M	$14.77M	$23.48M	$24.91M	$-58.79M

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Dec 31, 2025 10-K ↗	FY 2024 Dec 31, 2024 10-K ↗	FY 2023 Dec 31, 2023 10-K ↗	FY 2022 Dec 31, 2022 10-K ↗	FY 2021 Dec 31, 2021 10-K ↗	FY 2020 Dec 31, 2020 10-K ↗	FY 2019 Dec 31, 2019 10-K ↗	FY 2018 Dec 31, 2018 10-K ↗	FY 2017 Dec 31, 2017 10-K ↗	FY 2016 Dec 31, 2016 10-K ↗	FY 2015 Dec 31, 2015 10-K ↗	FY 2014 Dec 31, 2014 10-K ↗	FY 2013 Dec 31, 2013 10-K ↗	FY 2012 Dec 31, 2012 10-K ↗	FY 2011 Dec 31, 2011 10-K ↗	FY 2010 Dec 31, 2010 10-K ↗	FY 2009 Dec 31, 2009 10-K ↗	FY 2008 Dec 31, 2008 10-K ↗
Sales/Revenue/Turnover (USD)	$958.40M	$180.13M	$0.00	$0.00	$0.00	$0.00	$0.00	$0.00	—	—	—	—	—	—	—	—	—	—
Depreciation Expense (USD)	$1.51M	$1.10M	$527.00K	$467.00K	$405.00K	$471.00K	$112.00K	$96.00K	$77.00K	—	$662.00K	$673.00K	$516.00K	$738.00K	$1.46M	$1.93M	$2.46M	—
Net Income, GAAP (USD)	$-288.28M	$-465.89M	$-373.63M	$-295.35M	$-241.85M	$-202.24M	$-83.95M	$-32.81M	$-31.15M	$-26.39M	$-68.67M	$-86.16M	$-90.19M	$-62.79M	$-47.38M	$-37.47M	$79.09M	—
Operating Cash Flow (USD)	$-189.55M	$-455.57M	$-324.23M	$-224.86M	$-183.92M	$-157.56M	$-41.62M	$-25.51M	$-22.32M	$-17.61M	—	—	—	—	—	—	—	—

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bar_chart Data from SEC EDGAR XBRL filings

Synced 1 week ago 18 years · 68 quarters

MADRIGAL PHARMACEUTICALS, INC.

Analytical Summary

18-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

Statement lens

Benchmark Lens

Signals

Percentile Rankings

Peer Comparison

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