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Septerna, Inc.

SEPN

$38.45 ▼ -1.96 (-4.85%) at close

15 Visible periods

25 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

Septerna, Inc. faces fundamental challenges with weakness in Profit Margin (%) and Operating Margin (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $1.7B

Dividend Yield —

Revenue Growth 22375.6% ↗

Op. Margin -62.9% ↘

ROIC -4.7% ↘

FCF / Share $-0.49 ↗

Trailing P/E —

Price / Book 4.5x

FCF Yield —

Debt / Equity —

info Valuation on last close. End-of-day price, Sep 23, 2026.

15-Year Financial Trajectory

Quarterly

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$26.75M

↑ +22375.6% —

Net Income Profit after all expenses

$-8.64M

↑ +59.8% —

Operating Margin Operating profit as % of sales

-62.9%

↓ -25.5% 1th

FCF / Share Free cash flow per share

$-0.49

↓ -6.9% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Operating Margin (%)Operating Margin (%) is in the bottom quartile
Profit Margin (%)Profit Margin (%) is in the bottom quartile

Health Breakdown

Profitability

Returns ↓

Cash Quality ↑

Financial view

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📈 Is growth accelerating? 4 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Revenue Growth YoY (%)	22375.6% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+279595%)	12011.0% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+150037%)	11276.4% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+140855%)	12113.1% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+151313%)	-67.8% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-948%)	-30.9% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-486%)	79.7% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+896%)	433.3% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+5317%)	—	—	—	—	—	—	—
EPS Growth YoY (%)	48.2% Excellent Excellent Year-over-year change in earnings per share Optimal: > 10%	61.2% Excellent Excellent Year-over-year change in earnings per share Optimal: > 10%	N/M	N/M	92.0% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	92.3% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	-12.9% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	-54.1% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—	—
Net Income Growth YoY (%)	59.8% Excellent ↑ Excellent Improving Year-over-year change in net income	59.8% Excellent ↑ Excellent Improving Year-over-year change in net income	48.0% Excellent ↑ Excellent Improving Year-over-year change in net income	-52.3% Weak → Weak Stable Year-over-year change in net income	-51.6% Weak → Weak Stable Year-over-year change in net income	-51.6% Weak Weak Year-over-year change in net income	N/M	-53.7% Weak Weak Year-over-year change in net income	—	—	—	—	—	—	—
FCF Growth YoY (%)	-6.9% Weak Weak Year-over-year change in free cash flow	-9.5% Weak Weak Year-over-year change in free cash flow	—	N/M	91.8% Excellent Excellent Year-over-year change in free cash flow	93.1% Excellent Excellent Year-over-year change in free cash flow	—	—	—	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Operating Margin (%) (%)	-62.9% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-520%)	-50.1% Weak ↓ Weak Declining Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-434%)	-66.4% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-543%)	12.2% Fair Fair Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-19%)	—	—	—	—	—	—	—	—	—	—	—
Effective Tax Rate (%) (%)	-8.1% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-4.1% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.1% Excellent → Excellent Stable Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.0% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.8% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	0.7% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.7% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.7% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—	—
Profit Margin (%) (%)	-32.3% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-369%)	-32.6% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-371%)	-44.5% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-471%)	-99.9% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-933%)	—	—	—	—	—	—	—	—	—	—	—
FCF Margin (%) (%)	-82.9% Weak → Weak Stable Free cash flow as a percentage of revenue Optimal: > 10%	-99.8% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-62.4% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—	—	—	—	—	—	—	—	—	—	—
FCF / Net Income (x)	2.57x Excellent ↑ Excellent Improving Free cash flow relative to reported net income Optimal: > 1x	3.06x Excellent ↑ Excellent Improving Free cash flow relative to reported net income Optimal: > 1x	1.40x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	-7.86x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.95x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.10x Fair → Fair Stable Free cash flow relative to reported net income Optimal: > 1x	1.04x Fair ↓ Fair Declining Free cash flow relative to reported net income Optimal: > 1x	1.23x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	0.93x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	1.23x Good Good Free cash flow relative to reported net income Optimal: > 1x	-0.29x Weak Weak Free cash flow relative to reported net income Optimal: > 1x	—	—	—	—

🎯 Is capital allocation efficient? 3 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Return on Invested Capital (%)	-4.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-3.7% Weak → Weak Stable Return earned on debt + equity capital invested Optimal: > 10%	-4.2% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	0.7% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-7.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-6.5% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-5.8% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	25.6% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	26.8% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	30.0% Excellent ↑ Excellent Improving Return earned on debt + equity capital invested Optimal: > 10%	-70.6% Weak Weak Return earned on debt + equity capital invested Optimal: > 10%	12.9% Good Good Return earned on debt + equity capital invested Optimal: > 10%	—	—	—
Return on Capital (%) (%)	-3.0% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-2.3% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-2.7% Weak → Weak Stable Operating profit relative to total assets Optimal: > 10%	0.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	—	-6.0% Weak Weak Operating profit relative to total assets Optimal: > 10%	-5.4% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—	—	26.2% Excellent Excellent Operating profit relative to total assets Optimal: > 10%	—	—	—	—
Return on Common Equity (%) (%)	-2.2% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-115%)	-2.3% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-115%)	-2.8% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-119%)	-5.5% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-137%)	-5.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-138%)	-5.4% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-136%)	-4.9% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-133%)	16.1% Good ↑ Good Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+8%)	20.9% Excellent ↑ Excellent Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+39%)	27.3% Excellent ↑ Excellent Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+82%)	-90.9% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-706%)	12.4% Fair Fair Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-17%)	—	—	—

⚖️ Is the balance sheet risky? 1 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Net Debt (USD)	$-84.66M	$-71.61M	$-120.72M	$-319.99M	$-189.31M	$-210.04M	$-238.20M	$-88.24M	$-131.17M	$-81.34M	$-88.48M	$-98.52M	—	—	—

📊 What does each share earn? 6 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Revenue per Share (USD)	$0.59	$0.59	—	$0.48	$0.00	$0.00	—	$0.07	$0.16	$0.14	—	$0.02	—	—	—
Basic EPS, GAAP (USD)	$-0.29	$-0.19	$-0.24	$0.18	$-0.56	$-0.49	$14.61	$-8.40	$-7.03	$-6.35	$16.78	$-5.45	—	—	—
Free Cash Flow per Share (USD)	$-0.49	$-0.59	—	$3.81	$-0.46	$-0.54	—	$-7.12	$-5.62	$-7.83	—	—	—	—	—
Book Value per Share (USD)	$8.47	$8.43	$8.52	$8.71	$8.55	$9.01	$9.46	$-35.77	$-28.99	$-23.28	$-12.11	$-36.78	—	—	—
Tangible Book Value per Share (USD)	$8.47	$8.43	$8.52	$8.71	$8.55	$9.01	$9.46	$-35.77	$-28.99	$-23.28	$-12.11	$-36.78	—	—	—
Basic Weighted Avg Shares (shares)	45.04M	44.76M	—	44.34M	44.17M	43.94M	—	2.44M	2.34M	2.23M	—	2.01M	—	—	—

🏦 How resilient is the balance sheet? 2 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Working Capital (USD)	$316.84M	$289.89M	$324.03M	$416.40M	—	$331.83M	$343.98M	—	—	—	$105.76M	—	—	—	—
Total Equity (USD)	$386.72M	$378.46M	$381.93M	$388.73M	$377.56M	$400.27M	$420.05M	$-87.41M	$-67.76M	$-51.96M	$-38.37M	$-73.85M	$-63.26M	$-53.02M	$-44.20M

📋 What is driving earnings? 4 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Sales/Revenue/Turnover (USD)	$26.75M	$26.52M	$24.12M	$21.50M	$119.00K	$219.00K	$212.00K	$176.00K	$370.00K	$317.00K	$118.00K	$33.00K	—	—	—
Depreciation Expense (USD)	$400.00K	$400.00K	$400.00K	$400.00K	$400.00K	$400.00K	$400.00K	$400.00K	$300.00K	$300.00K	$200.00K	$200.00K	—	—	—
Net Income, GAAP (USD)	$-8.64M	$-8.64M	$-10.74M	$-21.48M	$-21.48M	$-21.48M	$-20.67M	$-14.10M	$-14.17M	$-14.17M	$34.89M	$-9.17M	—	—	—
Operating Cash Flow (USD)	$-22.18M	$-25.63M	$-14.99M	$168.81M	$-20.29M	$-23.34M	$-20.96M	$-16.81M	$-12.99M	$-16.71M	$-8.80M	—	—	—	—

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Synced yesterday 4 years · 15 quarters

Septerna, Inc.

Analytical Summary

15-Year Financial Trajectory

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Bearish Risks

Health Breakdown

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