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Twist Bioscience Corp

TWST

$158.55 ▼ -5.97 (-3.63%) at close

10 Visible periods

31 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

Twist Bioscience Corp faces fundamental challenges with weakness in Profit Margin (%) and Operating Margin (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $9.5B

Dividend Yield —

Revenue Growth 20.3% ↘

Op. Margin -36.2% ↗

ROIC -29.1% ↗

FCF / Share $-1.26 ↘

Trailing P/E —

Price / Book 20.3x

FCF Yield —

Debt / Equity —

info Valuation on last close. End-of-day price, Sep 23, 2026.

10-Year Financial Trajectory

Annual

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$376.57M

↑ +20.3% —

Net Income Profit after all expenses

$-77.67M

↑ +62.8% —

Operating Margin Operating profit as % of sales

-36.2%

↑ +48.7% 7th

FCF / Share Free cash flow per share

$-1.26

↓ -6.1% —

Long-Term Debt Long-term obligations

$1.40M

↓ -81.3% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Operating Margin (%)Operating Margin (%) is in the bottom quartile
Profit Margin (%)Profit Margin (%) is in the bottom quartile

Health Breakdown

Profitability ↑

Returns ↑

Cash Quality ↑

Financial view

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📈 Is growth accelerating? 6 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Revenue Growth YoY (%)	20.3% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+154%)	27.7% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+246%)	20.4% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+155%)	53.8% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+573%)	46.9% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+486%)	65.7% Excellent ↓ Excellent Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+721%)	113.9% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1324%)	136.2% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+1602%)	—	—
EPS Growth YoY (%)	63.9% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	0.0% Caution ↑ Caution Improving Year-over-year change in earnings per share Optimal: > 10%	10.9% Fair Fair Year-over-year change in earnings per share Optimal: > 10%	-28.3% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—
Net Income Growth YoY (%)	62.8% Excellent ↑ Excellent Improving Year-over-year change in net income	-2.0% Weak ↑ Weak Improving Year-over-year change in net income	6.1% Fair ↑ Fair Improving Year-over-year change in net income	-43.2% Weak ↓ Weak Declining Year-over-year change in net income	-8.7% Weak ↑ Weak Improving Year-over-year change in net income	-30.0% Weak ↑ Weak Improving Year-over-year change in net income	-51.1% Weak Weak Year-over-year change in net income	-20.1% Weak Weak Year-over-year change in net income	—	—
FCF Growth YoY (%)	-6.1% Weak ↓ Weak Declining Year-over-year change in free cash flow	60.2% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	28.7% Excellent Excellent Year-over-year change in free cash flow	-45.4% Weak Weak Year-over-year change in free cash flow	—	—	—	—	—	—
Revenue CAGR 3Y (%)	22.8% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	33.2% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	39.6% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	55.3% Excellent ↓ Excellent Declining Compound annual revenue growth over 3 years	73.3% Excellent Excellent Compound annual revenue growth over 3 years	103.0% Excellent Excellent Compound annual revenue growth over 3 years	—	—	—	—
Revenue CAGR 5Y (%)	33.1% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	41.9% Excellent ↓ Excellent Declining Compound annual revenue growth over 5 years	57.3% Excellent Excellent Compound annual revenue growth over 5 years	80.0% Excellent Excellent Compound annual revenue growth over 5 years	—	—	—	—	—	—

💰 Are margins durable? 5 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Operating Margin (%) (%)	-36.2% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-341%)	-70.6% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-570%)	-88.6% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-691%)	-115.3% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-869%)	-115.4% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-869%)	-155.5% Weak ↑ Weak Improving Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1136%)	-200.1% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1434%)	-277.5% Weak Weak Operating income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1950%)	—	—
Effective Tax Rate (%) (%)	-0.9% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.3% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.6% Excellent ↓ Excellent Declining Actual taxes paid relative to pre-tax income Optimal: 15-25%	4.6% Excellent ↑ Excellent Improving Actual taxes paid relative to pre-tax income Optimal: 15-25%	1.3% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	-0.3% Excellent Excellent Actual taxes paid relative to pre-tax income Optimal: 15-25%	—	—	—	—
Profit Margin (%) (%)	-20.6% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-272%)	-66.7% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-656%)	-83.5% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-796%)	-107.0% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-992%)	-114.9% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1058%)	-155.3% Weak ↑ Weak Improving Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1394%)	-198.0% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-1750%)	-280.2% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-2435%)	—	—
FCF Margin (%) (%)	-20.1% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-22.1% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-69.5% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-111.1% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-105.3% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-168.8% Weak ↑ Weak Improving Free cash flow as a percentage of revenue Optimal: > 10%	-188.8% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	-274.7% Weak Weak Free cash flow as a percentage of revenue Optimal: > 10%	—	—
FCF / Net Income (x)	0.97x Caution ↑ Caution Improving Free cash flow relative to reported net income Optimal: > 1x	0.33x Weak ↓ Weak Declining Free cash flow relative to reported net income Optimal: > 1x	0.83x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.04x Fair ↑ Fair Improving Free cash flow relative to reported net income Optimal: > 1x	0.92x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.09x Fair ↑ Fair Improving Free cash flow relative to reported net income Optimal: > 1x	0.95x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	0.98x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	0.98x Caution Caution Free cash flow relative to reported net income Optimal: > 1x	—

🎯 Is capital allocation efficient? 3 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Return on Invested Capital (%)	-29.1% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-46.8% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-35.0% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-28.4% Weak ↑ Weak Improving Return earned on debt + equity capital invested Optimal: > 10%	-26.0% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-41.6% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-53.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	28.7% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	34.6% Excellent Excellent Return earned on debt + equity capital invested Optimal: > 10%	—
Return on Capital (%) (%)	-21.2% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-35.9% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-28.0% Weak → Weak Stable Operating profit relative to total assets Optimal: > 10%	-24.4% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-21.8% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-35.1% Weak ↑ Weak Improving Operating profit relative to total assets Optimal: > 10%	-58.2% Weak Weak Operating profit relative to total assets Optimal: > 10%	-60.9% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—
Return on Common Equity (%) (%)	-16.4% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-209%)	-44.2% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-394%)	-32.8% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-319%)	-27.6% Weak ↑ Weak Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-284%)	-26.2% Weak → Weak Stable Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-275%)	-41.6% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-377%)	-70.8% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-572%)	35.4% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+136%)	44.5% Excellent Excellent Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Above avg (+196%)	—

⚖️ Is the balance sheet risky? 4 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Debt to Equity (x)	—	—	—	—	—	0.00x Excellent ↓ Excellent Declining Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-99%)	0.05x Excellent Excellent Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-92%)	-0.04x Excellent Excellent Total debt relative to shareholder equity Optimal: < 0.6x vs Sector: Below avg (-106%)	—	—
Interest Coverage (x)	—	—	—	-2934.70x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-416.15x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-177.99x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-84.12x Weak ↓ Weak Declining Operating income divided by interest expense Optimal: > 5x	-53.74x Weak Weak Operating income divided by interest expense Optimal: > 5x	-64.62x Weak Weak Operating income divided by interest expense Optimal: > 5x	—
Net Debt (USD)	$-183.05M	$-226.32M	$-286.47M	$-378.69M	$-465.83M	$-92.26M	$-39.23M	$-73.54M	$-31.23M	—
Debt / EBITDA (x)	—	—	—	—	—	-0.01x Excellent ↑ Excellent Improving Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.07x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	-0.11x Excellent Excellent Debt relative to earnings before interest, taxes, depreciation Optimal: < 2x	—	—

📊 What does each share earn? 6 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Revenue per Share (USD)	$6.30	$5.39	$4.31	$3.78	$2.74	—	—	—	—	—
Basic EPS, GAAP (USD)	$-1.30	$-3.60	$-3.60	$-4.04	$-3.15	—	—	—	—	—
Free Cash Flow per Share (USD)	$-1.26	$-1.19	$-2.99	$-4.20	$-2.89	—	—	—	—	—
Book Value per Share (USD)	$7.80	$8.03	$10.83	$13.97	$11.73	$7.46	$4.63	$-62.83	—	—
Tangible Book Value per Share (USD)	$6.44	$6.57	$9.34	$12.45	$11.28	$7.43	$4.59	$-63.18	—	—
Basic Weighted Avg Shares (shares)	59.81M	58.02M	56.88M	53.88M	48.25M	—	—	—	—	—

🏦 How resilient is the balance sheet? 3 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Working Capital (USD)	$241.56M	$275.77M	$350.93M	$505.82M	$483.44M	$298.84M	$129.78M	$77.13M	—	—
LT Debt (USD)	—	—	—	—	—	$1.40M	$7.50M	$7.22M	—	—
Total Equity (USD)	$472.96M	$472.69M	$623.43M	$789.38M	$580.82M	$336.26M	$152.08M	$-201.42M	$-133.36M	$-76.61M

📋 What is driving earnings? 4 metrics

Metric	FY 2025 Sep 30, 2025 10-K ↗	FY 2024 Sep 30, 2024 10-K ↗	FY 2023 Sep 30, 2023 10-K ↗	FY 2022 Sep 30, 2022 10-K ↗	FY 2021 Sep 30, 2021 10-K ↗	FY 2020 Sep 30, 2020 10-K ↗	FY 2019 Sep 30, 2019 10-K ↗	FY 2018 Sep 30, 2018 10-K ↗	FY 2017 Sep 30, 2017 10-K ↗	FY 2016 Sep 30, 2016 10-K ↗
Sales/Revenue/Turnover (USD)	$376.57M	$312.97M	$245.11M	$203.56M	$132.33M	$90.10M	$54.38M	$25.43M	$10.77M	—
Depreciation Expense (USD)	$24.85M	$31.43M	$29.31M	$16.51M	$9.75M	$6.68M	$6.11M	$5.73M	$5.02M	—
Net Income, GAAP (USD)	$-77.67M	$-208.73M	$-204.62M	$-217.86M	$-152.10M	$-139.93M	$-107.67M	$-71.24M	$-59.31M	—
Operating Cash Flow (USD)	$-47.63M	$-64.09M	$-142.47M	$-124.39M	$-112.24M	$-142.25M	$-87.94M	$-66.16M	$-51.30M	—

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Synced yesterday 10 years · 37 quarters

Twist Bioscience Corp

Analytical Summary

10-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

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