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Upstream Bio, Inc.

UPB

$5.47 ▲ +0.10 (+1.96%) at close

15 Visible periods

22 Metrics

Peer-ranked Benchmarks

Price Chart

Health

Poor

Bearish

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Analytical Summary

Upstream Bio, Inc. faces fundamental challenges with weakness in Return on Common Equity (%). The fundamentals warrant careful consideration of downside risks.

Market Cap $298.5M

Dividend Yield —

Revenue Growth -17.5% ↘

Op. Margin —

ROIC -12.4% ↘

FCF / Share $-0.65 ↗

Trailing P/E —

Price / Book 1.1x

FCF Yield —

Debt / Equity —

info Valuation on last close. End-of-day price, Sep 22, 2026.

15-Year Financial Trajectory

Quarterly

Metric Value Trend Year over Year Percentile

Revenue Total top-line sales

$773.00K

↓ -17.5% —

Net Income Profit after all expenses

$-40.59M

↓ -48.8% —

FCF / Share Free cash flow per share

$-0.65

↑ +10.5% —

trending_up

Bullish Indicators

No bullish signals detected.

warning

Bearish Risks

Return on Common Equity (%)Return on Common Equity (%) is in the bottom quartile

Health Breakdown

Returns

Cash Quality ↓

Financial view

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📈 Is growth accelerating? 4 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Revenue Growth YoY (%)	-17.5% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-319%)	82.7% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+934%)	9.0% Fair ↓ Fair Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+12%)	12.5% Good ↓ Good Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+57%)	83.7% Excellent ↑ Excellent Improving Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+947%)	-11.6% Weak ↓ Weak Declining Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-245%)	36.2% Excellent Excellent Year-over-year change in total revenue Optimal: > 10% vs Sector: Above avg (+353%)	-2.3% Weak Weak Year-over-year change in total revenue Optimal: > 10% vs Sector: Below avg (-128%)	—	—	—	—	—	—	—
EPS Growth YoY (%)	1.4% Caution ↓ Caution Declining Year-over-year change in earnings per share Optimal: > 10%	-47.1% Weak ↓ Weak Declining Year-over-year change in earnings per share Optimal: > 10%	N/M	90.9% Excellent → Excellent Stable Year-over-year change in earnings per share Optimal: > 10%	88.6% Excellent ↑ Excellent Improving Year-over-year change in earnings per share Optimal: > 10%	89.1% Excellent Excellent Year-over-year change in earnings per share Optimal: > 10%	N/M	-229.9% Weak Weak Year-over-year change in earnings per share Optimal: > 10%	—	—	—	—	—	—	—
Net Income Growth YoY (%)	-48.8% Weak ↑ Weak Improving Year-over-year change in net income	-48.8% Weak ↑ Weak Improving Year-over-year change in net income	-99.9% Weak ↑ Weak Improving Year-over-year change in net income	-150.3% Weak ↓ Weak Declining Year-over-year change in net income	-150.3% Weak ↑ Weak Improving Year-over-year change in net income	-150.3% Weak ↑ Weak Improving Year-over-year change in net income	-79.5% Weak Weak Year-over-year change in net income	-255.8% Weak Weak Year-over-year change in net income	—	—	—	—	—	—	—
FCF Growth YoY (%)	10.5% Fair ↓ Fair Declining Year-over-year change in free cash flow	-14.7% Weak ↓ Weak Declining Year-over-year change in free cash flow	—	91.0% Excellent ↑ Excellent Improving Year-over-year change in free cash flow	72.7% Excellent Excellent Year-over-year change in free cash flow	86.9% Excellent Excellent Year-over-year change in free cash flow	—	—	—	—	—	—	—	—	—

💰 Are margins durable? 2 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Profit Margin (%) (%)	—	—	—	—	—	—	—	—	—	—	—	-493.1% Weak Weak Net income as a percentage of revenue Optimal: > 15% vs Sector: Below avg (-4209%)	—	—	—
FCF / Net Income (x)	0.88x Caution → Caution Stable Free cash flow relative to reported net income Optimal: > 1x	1.18x Fair ↑ Fair Improving Free cash flow relative to reported net income Optimal: > 1x	0.72x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	0.82x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.44x Good ↑ Good Improving Free cash flow relative to reported net income Optimal: > 1x	1.51x Excellent ↑ Excellent Improving Free cash flow relative to reported net income Optimal: > 1x	0.93x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.28x Good → Good Stable Free cash flow relative to reported net income Optimal: > 1x	0.74x Caution ↓ Caution Declining Free cash flow relative to reported net income Optimal: > 1x	1.61x Excellent Excellent Free cash flow relative to reported net income Optimal: > 1x	1.36x Good Good Free cash flow relative to reported net income Optimal: > 1x	—	—	—	—

🎯 Is capital allocation efficient? 3 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Return on Invested Capital (%)	-12.4% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-11.3% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-10.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-7.9% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-8.6% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-5.7% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	-4.4% Weak ↓ Weak Declining Return earned on debt + equity capital invested Optimal: > 10%	9.3% Fair → Fair Stable Return earned on debt + equity capital invested Optimal: > 10%	9.5% Fair ↑ Fair Improving Return earned on debt + equity capital invested Optimal: > 10%	8.9% Fair ↑ Fair Improving Return earned on debt + equity capital invested Optimal: > 10%	9.2% Fair Fair Return earned on debt + equity capital invested Optimal: > 10%	6.6% Caution Caution Return earned on debt + equity capital invested Optimal: > 10%	—	—	—
Return on Capital (%) (%)	-15.1% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-13.7% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-13.0% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	-9.7% Weak ↓ Weak Declining Operating profit relative to total assets Optimal: > 10%	—	-7.0% Weak Weak Operating profit relative to total assets Optimal: > 10%	-5.5% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—	—	-12.2% Weak Weak Operating profit relative to total assets Optimal: > 10%	—	—	—	—
Return on Common Equity (%) (%)	-15.0% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-200%)	-13.4% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-189%)	-12.5% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-183%)	-7.2% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-148%)	-6.7% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-144%)	-6.1% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-141%)	-4.5% Weak ↓ Weak Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-130%)	6.8% Caution ↓ Caution Declining Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-55%)	7.4% Caution ↑ Caution Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-50%)	8.2% Caution ↑ Caution Improving Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-46%)	9.6% Caution Caution Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-36%)	2.7% Weak Weak Profit generated per dollar of shareholder equity Optimal: > 15% vs Sector: Below avg (-82%)	—	—	—

⚖️ Is the balance sheet risky? 1 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Net Debt (USD)	$-79.40M	$-96.72M	$-101.58M	$-72.16M	$-45.46M	$-71.31M	$-325.89M	$-32.95M	$-47.34M	$-31.51M	$-25.83M	$-47.32M	—	—	—

📊 What does each share earn? 6 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Revenue per Share (USD)	$0.01	$0.02	—	$0.01	$0.02	$0.01	—	$0.20	$0.17	$0.21	—	$0.21	—	—	—
Basic EPS, GAAP (USD)	$-0.73	$-0.75	$-0.78	$-0.63	$-0.74	$-0.51	$12.57	$-6.96	$-6.50	$-4.68	$-5.05	$-2.11	—	—	—
Free Cash Flow per Share (USD)	$-0.65	$-0.88	—	$-0.41	$-0.73	$-0.77	—	$-4.62	$-2.67	$-5.86	—	—	—	—	—
Book Value per Share (USD)	$4.95	$5.59	$6.26	$7.01	$7.60	$8.31	$8.77	$-53.03	$-48.73	$-44.53	$-41.15	$-37.92	—	—	—
Tangible Book Value per Share (USD)	$4.95	$5.59	$6.26	$7.01	$7.60	$8.31	$8.77	$-53.03	$-48.73	$-44.53	$-41.15	$-37.92	—	—	—
Basic Weighted Avg Shares (shares)	54.57M	54.33M	—	53.93M	53.77M	53.62M	—	3.02M	3.01M	3.00M	—	2.96M	—	—	—

🏦 How resilient is the balance sheet? 2 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Working Capital (USD)	$269.61M	$302.61M	$338.35M	$377.11M	—	$444.22M	$468.42M	—	—	—	$110.48M	—	—	—	—
Total Equity (USD)	$270.96M	$304.00M	$339.77M	$378.58M	$408.74M	$445.61M	$469.85M	$-160.31M	$-146.61M	$-133.41M	$-123.13M	$-112.20M	$-109.87M	$-107.91M	$-106.16M

📋 What is driving earnings? 4 metrics

Metric	Q2 FY2026 Jun 30, 2026 10-Q ↗	Q1 FY2026 Mar 31, 2026 10-Q ↗	Q4 FY2025 Dec 31, 2025 10-K ↗	Q3 FY2025 Sep 30, 2025 10-Q ↗	Q2 FY2025 Jun 30, 2025 10-Q ↗	Q1 FY2025 Mar 31, 2025 10-Q ↗	Q4 FY2024 Dec 31, 2024 10-K ↗	Q3 FY2024 Sep 30, 2024 10-Q ↗	Q2 FY2024 Jun 30, 2024 10-Q ↗	Q1 FY2024 Mar 31, 2024 10-Q ↗	Q4 FY2023 Dec 31, 2023 10-K ↗	Q3 FY2023 Sep 30, 2023 10-Q ↗	Q2 FY2023 Jun 30, 2023 10-Q ↗	Q1 FY2023 Mar 31, 2023 10-Q ↗	Q4 FY2022 Dec 31, 2022 10-K ↗
Sales/Revenue/Turnover (USD)	$773.00K	$1.03M	$668.00K	$683.00K	$937.00K	$566.00K	$613.00K	$607.00K	$510.00K	$640.00K	$450.00K	$621.00K	—	—	—
Depreciation Expense (USD)	$50.00K	$49.00K	$57.00K	$46.00K	$42.00K	$43.00K	$49.00K	$14.00K	$13.00K	$13.00K	$14.00K	—	—	—	—
Net Income, GAAP (USD)	$-40.59M	$-40.59M	$-42.46M	$-27.27M	$-27.27M	$-27.27M	$-21.24M	$-10.89M	$-10.89M	$-10.89M	$-11.83M	$-3.06M	—	—	—
Operating Cash Flow (USD)	$-35.62M	$-47.85M	$-30.63M	$-22.24M	$-39.24M	$-41.16M	$-19.61M	$-13.96M	$-8.04M	$-17.56M	$-16.11M	—	—	—	—

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Synced yesterday 4 years · 15 quarters

Upstream Bio, Inc.

Analytical Summary

15-Year Financial Trajectory

Bullish Indicators

Bearish Risks

Health Breakdown

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